If you have type 2 diabetes
There are certain factors that you should consider if you have type 2 diabetes and are wondering if it’s okay to take a couple of ibuprofen for your headache, backache, or fever [4].
Metformin use
Many people with type 2 diabetes take metformin to help them control their blood sugar levels. Metformin belongs to a class of drugs known as biguanides.
Metformin lowers the amount of glucose that your liver makes and the amount of glucose that you absorb from the food you eat. It also has some anti-inflammatory effects. Some research suggests that metformin may interact with ibuprofen and other analgesics.
One 2017 study suggested that they actually interacted “synergistically” and that lower doses of ibuprofen would be adequate for a person already taking metformin to get the pain relief they needed. But that study was conducted with animals, and more research is needed.