Chronic kidney disease
Your doctor will most likely instruct you to do away with ibuprofen if you have kidney disease. The study has shown that the use of NSAIDs [5] for a long period of time, if you have type 2 diabetes, increases your risk of developing chronic kidney disease.
Hypoglycemia
Hypoglycemia may also be a concern for people with type 2 diabetes. Research suggests that people who are receiving treatment with sulfonylureas, which is used to stimulate the beta cells in your pancreas to release more insulin, might be at increased risk for hypoglycemia.
Since sulfonylureas can potentially lead to low blood sugar anyway, ibuprofen might compound the effect.