Calcineurin Inhibitors
Topical calcineurin inhibitors [7] are anti-inflammatory substances that inhibit the activation of calcineurin-dependent T cells, thereby preventing the production of cytokines and pro-inflammatory mediators, but without compromising the body’s immune function.
Calcineurin inhibitors are recommended in patients who do not respond well to other topical treatments or when they cannot use corticosteroids. Examples include Pimecrolimus and Tacrolimus, which help to increase the skin’s defenses and make it look normal and healthy while preventing itching from occurring. Both should be applied twice a day, from the first sign of the cutaneous lesions to a maximum of one week after they disappear.
The most common side effects are localized local reactions, including burning, burning, and itching, which commonly occurs during the first week of treatment. As they do not have the same side effects as topical corticosteroids, they can be used more safely on the face, genitals, and areas close to mucous membranes.