Genetic Influence
More than 50 genes [5] that is associated with lupus have now been identified by researchers. These genes are more often found in individuals that have lupus than in those without the disorder, and although several of these genes have not been conclusively proven cause lupus directly, they are suspected to contribute to it.
Genes aren’t adequate in most instances. This is particularly noticeable with twins that are raised in the same setting and have the same genetic traits, but only one develops lupus. However, there is an increased risk that the other twin will also have the disorder when one of the two identical twins already developed it (30 percent possibility in identical twins; 5-10 percent probability in fraternal twins.
There is still a possibility that lupus develops in an individual who doesn’t have any family history of members with lupus. Although, it is not uncommon for the family members to have some sort of auto immune disease.
Some ethnic groups (people of descent from African, Hispanic/Latino, Asian, Native Hawaiian Native American or Pacific Island) have a higher risk of later developing lupus, which is most likely due to genes common to them.