Changes in Hormones in the Testicles
Another major cause of benign prostatic hyperplasia is a result of changes in the hormones in the testicles. The male reproductive system produces testosterone and little amounts of estrogen. However, as time lapses, the level of testosterone reduces in the blood, leaving a higher portion of estrogen in it. According to research, BPH may happen as a result of the increased activity of estrogen, causing the prostate cells to start to grow.
Another theory is that, as dihydrotestosterone [3] (a male hormone that helps in prostate development) starts to rise, the testosterone levels drop in the blood. As a result of the continuous increase of dihydrotestosterone in the blood, the prostate may be forced to continue growing.
It has been noted that men whose testicles were removed before puberty, do not develop benign prostatic hyperplasia in the future, the same applied to men who do not produce testosterone.