RNASEL, Also Known as HPC1
RNASEL is a tumor suppressor gene that has its primary function of helping cells die when something goes wrong and start to act abnormally. If this gene suffers from some inherited mutation, it could cause abnormal cells to live longer than they should, which can increase the risk of prostate cancer.
BRCA1 and BRCA2
These are also tumor suppressor genes, which has its main function of helping to repair mistakes in a cell’s DNA. If the gene experiences inherited gene mutation, it increases the risk of prostate cancer and breast and ovarian cancer in women.
DNA Mismatch Repair Genes
Examples of DNA mismatch repair genes include; MSH2, MSH6, PMS2, and MLH1. These genes help fix mistakes in DNA, errors that are made when a cell is preparing to divide into two new cells. An inherited mutation in these genes is called Lynch syndrome, which increases the risk of several cancers, including prostate cancer.
Other inherited mutated genes that have been linked to prostate cancer include; HOXB13, CHEK2, ATM, PLAB2, and RAD51D.