- Calcineurin Inhibitors
Calcineurin inhibitors help reduce inflammation and plaque buildup [3] on the skin. They are sold as ointments and creams that can be applied on sensitive areas of skin where topical corticosteroids may be harmful. They may be used on areas of thin skin, such as around the eyes, scalp, genital areas, and other skin folds.
You should not use calcineurin inhibitors if you are pregnant or breastfeeding. It is also not recommended for long-term use because it increases the risk of cancer and lymphoma. When using calcineurin inhibitors, you may experience side effects like burning or itching, but these typically disappear within one week.
- Coal Tar
Coal tar is effective in reducing psoriasis symptoms [4], such as scaling, itching, and inflammation. The mechanism of action is not clear, but it has been used for many years in treating psoriasis. It is possibly the oldest known treatment. It may also be gotten in various forms, such as shampoo, oil, and cream. It may be applied to affected parts of the scalp, torso, and limbs.
The downside of treating psoriasis with coal tar is that it may cause skin irritation. Pregnant and breastfeeding women with psoriasis should not use this treatment.