Xanthomas
Xanthoma [6] corresponds to the appearance of very strange subcutaneous bumps, formed by fats that can appear on any part of the body, but mainly on the tendons, skin, hands, feet, glutes, and knees. The appearance of xanthoma is more pronounced in individuals that have very high triglycerides or cholesterol. (Note that people that do not have cholesterol fluctuations may also manifest xanthomas).
The presence of xanthoma is usually a sign that there is a greater amount of circulating cholesterol, which caused macrophages, which are cells of the immune system, to encompass fat cells, transforming into foamy macrophages and being deposited in the tissue. Thus, xanthoma is not a disease, but a symptom associated with a defect in the metabolism of fats and proteins that carry cholesterol in the body.