Biologicals Immunosuppressant
Drugs that suppress the activity of the immune system (immunosuppressant) or antibodies to the TNF inflammatory neurotransmitter can positively affect the course of the disease
The so-called biologics [7], which have a strong anti-inflammatory effect, are very effective, that is, targeted antibodies directed against tumor necrosis factor (alpha-TNF – a signaling agent of the immune system involved in inflammation), as well as inhibiting the migration of lymphocytes to the area of inflammation. This means that they work by suppressing the immune system response that starts the inflammation process.
It has been proven to be very effective for patients with moderately active ulcerative colitis, including in cases where conventional therapy does not help.
Biologics are an important step in therapy. Some of them are still under development. Given their medium- to long-term efficacy and favorable safety profile, they are expected to be increasingly used as maintenance therapy or even as part of combination therapy.
Oher effective immune system suppressants [8] are;
- Azathioprine and mercaptopurine: administering these drugs [9] requires recurring medical consultations to check your health, including possible side effects it may have on your liver and pancreas. Other side effects may involve infection resistance and the possibility of having cancers, e.g., skin cancers and lymphoma.
- Cyclosporine: This drug [10] is often used for patients that do not respond well to other treatment medication. This drug has a high risk for serious side effects such as liver damage and effects on the kidney, infections, and seizures. It is not recommended for long-term use.
Corticosteroids can also be used in conjunction with an immune system suppressant.