S-Adenosylmethionine (SAMe)
SAMe is a compound produced naturally in the body. It plays an important role in brain function and may be useful in treating depression.
A recent review of studies [21] found that using this compound alone or in combination with antidepressants was effective in improving symptoms of depression in people with major depressive disorder. The doses used in these studies were between and 200 to 3,200 milligrams and the studies lasted between 2 to 12 weeks.
More research is needed before SAMe can be approved for treating depression. According to doctors from Mayo Clinic [22], high doses of SAMe may cause nausea and vomiting. If used with antidepressants, SAMe may cause serious side effects.