Nasal Sprays for the Treatment of Migraine

Migraine Crystal L.

Different types of migraine nasal sprays

It is important that the nasal spray you use is approved by the Food and Drug Administration (FDA) [6]. Different nasal sprays that are approved and recommended include:

Imitrex. Imitrex is a nasal spray that belongs to the triptan drug sumatriptan. It was approved by the FDA in 1997 and is highly recommended for the acute treatment of migraine attacks with or without aura in adults.
Migranal. Migranal is a nasal spray of the ergotamine dihydroergotamine. It was approved by the FDA in 1997 and is indicated for acute migraine attacks with or without aura in adults.
Zomig. Zomig is a nasal spray of the triptan drug zolmitriptan. It was approved by the FDA in 2003 and is indicated for helping to treat an acute migraine attack that occurs with or without aura in adults.
Tosymra. Tosymra is also a nasal spray of the triptan drug sumatriptan. It was approved by the FDA in 2019 and, like Imitrex, is indicated for the treatment of an acute migraine attack with or without aura in adults.
Sprix. Sprix is a nasal spray that belongs to the NSAID ketorolac. It received its FDA approval in 1989 and is highly recommended for the treatment of moderate to severe pain in adults.

There are also some recent advances in nasal spray technology. For example, according to Impel NeuroPharma, a new drug application has been submitted to the FDA for INP104, which uses new technology to deliver a dihydroergotamine nasal spray.

Known as precision olfactory delivery (POD) [7], this technology was made to deliver the spray into the upper part of your nasal cavity, where it can be more effectively absorbed into your bloodstream than the currently available nasal sprays.

Conclusion

Nasal sprays are effective to help treat and ease the symptoms of an acute migraine attack. They can also often work to ease your symptoms faster than oral abortive medications. There are different types of nasal sprays, it is best that you allow your doctor to prescribe to you which is best for your condition.

References

[1] https://www.mayoclinic.org/diseases-conditions/migraine-headache/symptoms-causes/syc-20360201

[2] https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.12045

[3] https://www.nhs.uk/conditions/migraine/symptoms/

[4] https://www.webmd.com/migraines-headaches/triptans-migraines

[5] https://my.clevelandclinic.org/health/drugs/11086-non-steroidal-anti-inflammatory-medicines-nsaids

[6] https://www.fda.gov/

[7] https://impelnp.com/our-science/pod-technology/

Crystal L. February 9, 2022

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