Prevention
There are several approaches to prevent mitochondrial dysfunction from occurring. Firstly, NAD+ supplements can help deal with the problems with NAD+. This method helps slow down the buildup of this damage in the body. Another way is to move the most important parts of the mitochondrial DNA to the nucleus, another part of the body cell. This can allow for better repair mechanisms of the DNA and prevent it from the effects of reactive oxygen species. [8]
Long-Term Outlook
Mitochondrial dysfunction is basically a part of the aging process. The long-term outlook for those with this condition largely depends on the severity and number of affected tissues and organs. In some cases, affected people would live a normal life. Others would go through major changes over a period of time. Flare-ups might occur sometimes and then remain dormant for several years. Even though there is still no cure for mitochondrial dysfunction, more research is still focusing on it. Those people with this disorder who want to have children should visit a genetic expert to find out possible risks. [9]
Reference：
[1]https://www.genome.gov/genetics-glossary/Mitochondria
[2]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449
[3]https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases
[4]https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases
[5]https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases
[6]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405934/
[7]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405934/
[8]https://academic.oup.com/hmg/article/20/R2/R168/640414
[9]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449/