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Overview of Demyelinating Disorders

Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth disease (CMT) also causes damage to the peripheral nerves. It is an inherited condition that results from a genetic mutation that can impact the structure or function of myelin.

Symptoms of CMT include:

  • Weak muscles in the limbs
  • Changes to walking, often with frequent tripping or falling
  • Foot irregularities, such as high arches or curled toes
  • A reduced ability to feel sensations such as touch and temperature
  • Muscle cramping
  • Peripheral neuropathy

CMT is progressive, which means that the symptoms gradually become worse. People with the condition typically experience increasing difficulty with movement and carrying out daily tasks.<