Friction
Repetitive friction or rubbing can cause blisters. These blisters usually appear on the feet or hands because these are the areas that usually encounter repetitive abrasion. Whether you’re walking, running, or playing the drums, the legs and hands experience more friction.
Parts of skin that have a thick horny layer and are attached tightly to underlying structures (such as palms of hands and soles of feet) are more likely to generate blisters.
Blisters are more likely to occur if the conditions are warm, like inside a shoe. They are also more likely to form in damp conditions, compared with dry or wet environments. Although rare, blisters are also known to cause more serious medical conditions like infection and ulceration. [3]