Gout
This is another health condition that can cause severe pain in your ankle. It is a type of inflammatory arthritis that occurs as a result of the buildup of uric acid crystals in the joints. It most commonly affects the big toe but can also affect other joints in the body including the ankle. An attack from gout can come on suddenly.
Lupus
Lupus is another autoimmune disease that causes inflammation. Parts of its symptoms include swelling, muscle pain, and joint pain in various parts of the body, including the feet and ankles. About 70 percent of people with lupus wind up with arthritis in their feet.
Fallen arches
Fallen arches occur when the tendons supporting the arches of your feet get damaged, causing the arches to lose support. This condition is very similar to having flat feet [2].