Medications Affecting Calcium Channels
Several drugs such as gabapentin (Neurontin, gralise), gabapentin enacarbil (horizontal) and pregabalin (Lyrica), work for some people with RLS.
Muscle Relaxants and Sleeping Drugs: These medications help with the sleep cycle, they also allow you to sleep better at night. However, they do not eradicate the leg sensations, and they cause daytime drowsiness. These drugs are mainly used when no other treatment is giving results.
Opioids: Narcotic medications help to relieve mild and complicated symptoms of RLS. However, they can be addictive when used in high quantities. Examples are tramadol (Ultram, ConZip), codeine, oxycodone (Oxycontin, Roxicodone, others) and hydrocodone (Hysingla ER, Zohydro ER).
It usually takes a long time before a doctor fonds the right drugs for a patient because each of these drugs have a side effect.
Conclusion
There is no permanent cure for restless legs syndrome, but these treatments and natural remedies can help relieve the symptoms.
Reference:
[1] http://www.webmd.com/
[2] http://www.webmd.com/
[3] http://www.healthline.com/
[4] http://www.mayoclinic.org/
[5] http://www.medicinenet.com/
[6] http://www.medicalnewstoday.com/