Headache
Head is not among the popular symptoms of this disease but may occur in some people. The infection may cause a cytokine storm, a condition where there is a significant rise of cytokine levels [6] in the bloodstream, causing headaches. Cytokine is the protein responsible for sending signals to the immune system to fight invaders. The elevated cytokine levels is the body trying to fight the parasite by flushing it out. While the amino acids are useful, they are also responsible for causing some of the symptoms associated with the disease, including headaches.
Some anti-malaria medications may have headaches as a side effect in some persons. If this symptom persists after recovering from the infection, it may be due to post-malaria neurologic syndrome.