- Natalizumab And Vedolizumab
These medications [4] prevent certain immune cell molecules called integrins from binding to cells in the wall of your intestines. Of these two types of biologics, natalizumab puts you at risk of leukoencephalopathy and is only given to those enrolled in a restricted distribution program. Leukoencephalopathy is a serious brain disease that may lead to death or disability. While the possibility of getting it due to this medication is rare, it is too important to leave it to chance.
The other biologic called vedolizumab does not carry the risk of this brain disease. It is a new biologic approved for the treatment of Crohn’s disease. It works in the same way natalizumab does. The main brand names of natalizumab and vedolizumab are Tysabri and Entyvio respectively.