Enlarged spleen
Sometimes the problem is not as much a decrease in platelet production as it is that the platelets do not all reach their destination. Platelets can get trapped in the spleen [3] and cause the number circulating in your blood to drop significantly. This typically happens when the spleen is enlarged.
The spleen is a dark red, oval organ located in the left side of the abdomen, between the stomach and diaphragm. It is a vital part of the immune system that helps to fight infections. It is normally about the size of your fist. Certain disorders cause the spleen to enlarge and this might cause it to trap ore platelets instead of releasing them to the blood.