During the biopsy
While the area is numb, your radiologist will use a specific biopsy needle, one that is several inches in length, hollow, and wider than those used for regular shots. This needle is what makes it possible for them to obtain a tissue sample.
An incision might be made in your skin to allow for easy insertion of the biopsy needle. How deep the needle goes in depends on the location of the abnormal tissue. Your radiologist then extracts the samples of the abnormal tissues. This may feel like pressure or even sharp pain.
During the procedure, your radiologist will ask that you remain still and avoid coughing. When it is time to remove a tissue sample, you will need to hold your breath. Several samples may be needed.